12、15(2):431-440,Clinical applications of metabolomics in oncology,1. Search early diagnostic biomarkers,Breast cancer: tCho glycerophosphocholine glucose,2. Response assessment to chemical drugs/therapy treatments,Both as a predictive measure of efficacy and a pharmacodynamic marker,Tiziani S, Lodi A, 。

13、 Khanim FL, Viant MR, Bunce CM, et al. PLoS ONE, 2009, 4(1):e4251,Bathen TF, et al. Breast Cancer Res Treat, 2007;
104:181189,Some knowledge about prostate cancer,1. Prostate cancer the most frequently diagnosed cancer in men,2. current diagnostic methods: using a combination of digital rectal examin 。

14、ation and measuring the levels of the enzyme PSA in the blood serum,3. limitation of current diagnosis: the features of this kind of cancer are notoriously variable among patients,Metabolomic profiling of prostate cancer,Screekumar A., et al. Nature, 2009 Feruary 12, 457(7231):910-914,a, Venn diagra 。

15、m of the total metabolites detected across 42 prostate-related tissues and 110 matched plasma and urine samples. b, Venn diagram of 626 metabolites in tissues measured across 16 benign adjacent prostate tissues, 12 clinically localized prostate cancers (PCA) and 14 metastatic prostate cancers (Mets, 。

16、Screekumar A., et al. Nature, 2009 Feruary 12, 457(7231):910-914,Metabolomic profiling of prostate cancer,Screekumar A., et al. Nature, 2009 Feruary 12, 457(7231):910-914,Hierarchical cluster analysis of prostate tissue samples,Screekumar A., et al. Nature, 2009 Feruary 12, 457(7231):910-914,blue ci 。

17、rcles-benign adjacent prostate,yellow squares-localized prostate cancer,red triangles-metastatic prostate cancer,Principal components analysis of prostate tissue samples,Screekumar A., et al. Nature, 2009 Feruary 12, 457(7231):910-914,blue-benign;
yellow-localized,two-tailed Wilcoxon rank sum test,Screekumar A., et al. Nature, 2009 Feruary 12, 457(7231):910-914,yellow-localized;
red-metastatic,Screekumar A., et al. Nature, 2009 Feruary 12, 457(7231):910-914,A role for sarcosine in prostate cancer cell invasion and androgen signaling,Thank you 。

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