如：碳水化合物、氨基酸、肽、抗体、叶酸、表面活性剂等40-42 。
树状大分子也可以 。

19、与各种载体相连如脂质体43、纳米粒44、碳纳米管45等（Fig.5） 。
59.结语纳米技术在生物医学领域中的应用 ， 准确选择药物运载体系是其关键 。
树状大分子在生物医学、药剂学、生物药剂学等领域具有广阔的应用前景 。
树状大分子相比于其它大分子的优点在于能够精确控制粒径、表面官能团 ， 且具有高单分散性 ， 是新一代药物载体 。
树状大分子作为多样化的药物载体 ， 可运载药物、基因、蛋白质、肽、寡聚核苷酸等 。
然而基于树状大分子的运载体系的高效的、有针对性的建立与应用还要走很长的路 。
参考文献1 Buhleier E, Wehner W, Vogtle F. Cascade and nonskid-chain-like s 。

20、yntheses of molecular cavity topologies. Synthesis 1978;
2:1558.2 Tomalia DA, Baker H, Dewald JR, Hall M, Kallos G, Martin S, Roeck J, Ryder J, Smith P. A new class of polymers:star burst dendritic macromolecules. Polymer Journal 1985;
17:11732.3 Kumar P, Meena KP, Kumar P, Choudhary C, Thakur DS, Baj 。

21、payee P. Dendrimer: a novel polymer for drug delivery. Journal of Innovative Trends in Pharmaceutical Sciences 2010;
1:25269.4 Esfand R, Tomalia DA. Poly(amidoamine) (PAMAM) dendrimers:from biomimicry to drug delivery and biomedical applications. Drug Discovery Today 2001;
6:42736.5 Gillies ER, Dy E,。

22、Frechet JMJ, Szoka FC. Biological evaluation of polyester dendrimer: poly(ethylene oxide) “bow-tie” hybrids with tunable molecular weight and architecture. Molecular Pharmaceutics 2005;
2:12938.6 Fuchs S, Kapp T, Otto H, Schoeneberg T, Franke P, Gust R, Schlueter AD. A surface-modified dendrimer set。

23、for potential application as drug delivery vehicles: synthesis, in vitro toxicity, and intracellular localization. ChemistryA European Journal 2004;
10:1167927 Kesharwani P, Gajbhiye V, Tekade RK, Jain NK. Evaluation of dendrimer safety and efficacy through cell line studies. Current Drug Targets 201 。

24、1;
12:147897.8 Leroueil PR, Berry SA, Duthie K, Han G, Rotello VM, McNerny DQ, Baker Jr JR, Orr BG, Holl MM. Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers. Nano Letters 2008;
8:4204.9 El-Sayed M, Ginski M, Rhodes C, Ghandeharia H. Transepithelial transport of poly 。

25、(amidoamine) dendrimers across caco-2 cell monolayers. Journal of Controlled Release 2002;
81:3556510 Wolinsky JB, Grinstaff MW. Therapeutic and diagnostic applications of dendrimers for cancer treatment. Advanced Drug Delivery Reviews 2008;
60:103755.11 Asthana A, Chauhan AS, Diwan PV, Jain NK. Poly( 。

26、amidoamine) dendritic nanostructures for controlled site specific delivery of acidic anti-inflammatory active ingredients. AAPS PharmSciTech: An Offical Journal of the American Association of Pharmaceutical Scientists 2005;
6:53678.12 Gupta U, Agashe HB, Jain NK. Poly (propylene imine) dendrimer medi 。

27、ated solubility enhancement, effect of pH and functional groups of hydrophobes. Journal of Pharmacy and Pharmaceutical Sciences 2007;
10:35867.13 Shi X, Bnyai I, Rodriguez K, Islam MT, Lesniak W, Balogh P, Balogh LP, Baker Jr JR. Electrophoretic mobility and molecular distribution studies of poly(ami 。

28、doamine) dendrimers of defined charges.Electrophoresis 2006;
27:175867.14 Nanjwade BK, Bechra HM, Derkara GK, Manvi FV, Nanjwade VK. Dendrimers: emerging.polymers for drug-delivery systems. European Journal of Pharmaceutical Sciences 2009;
38:1859615 Schilrreff P, Mundi na-Weilenmann C, Romero EL, Mor 。

29、illa MJ. Selective cytotoxicity of PAMAM G5 corePAMAM G2.5 shell tecto-dendrimers on melanoma cells. International Journal of Nanomedicine 2012;
7:412133.16 Welch PM, Welch CF. Tecto-dendrimers : a study of covalently bound nanospheres. Macromolecules 2009;
42:75718.17 Scott H Medina ，Shewach ，William 。

30、 ，D Ensminger, et al NAcetyl galactosamine functionalized dendrimers as hepatic cancer cell Targeted carriers.Biomaterials ， 2011 ， 32: 4118412918 YuanYue ， Jae Soon Eun ， Mi Kyung Lee ， et al Synthesis and characterization Of G5 PAMAM dendrimer containing daunorubicin for targeting cancer cells. Archives of。

31、Pharmacal Reserch 2012 ， 35( 2) : 34334919Qian Zhang ， Na Wang ， Tongwen Xu ， et al Poly( amidoamine) dendronized hollow fiber membranes: Synthesis ， characterization ， and preliminary applications as drug delivery devices. Acta Biomaterialia ， 2012(8) : 1316132220 Darbre T, Reymond JL. Peptide dendrimers as arti 。

32、ficial enzymes receptors and drug-delivery agents. Accounts of Chemical Research 2006;
39:92534.21 Pushechnikov A, Jalisatgi AA, Hawthorne MF. Dendritic closomers: novel spherical hybrid dendrimers. Chemical Communications 2013;

稿源：(未知)

【傻大方】网址：/a/2021/0801/0023375091.html

标题：树状大分子作为药物运载体系的研究进展|树状大分子作为药物运载体系的研究进展 - 副本 - 副本( 四 )